Risk of Benign Gynecologic Tumors in Relation to Prenatal Diethylstilbestrol Exposure

OBJECTIVE:To investigate the association between prenatal diethylstilbestrol (DES) exposure and risk of benign gynecologic tumors. METHODS:We conducted a collaborative follow-up study of women with and without documented intrauterine exposure to DES. We compared the incidence of self-reported ovaria...

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Bibliographic Details
Published inObstetrics and gynecology (New York. 1953) Vol. 105; no. 1; pp. 167 - 173
Main Authors Wise, Lauren A., Palmer, Julie R., Rowlings, Kathleen, Kaufman, Raymond H., Herbst, Arthur L., Noller, Kenneth L., Titus-Ernstoff, Linda, Troisi, Rebecca, Hatch, Elizabeth E., Robboy, Stanley J.
Format Journal Article
LanguageEnglish
Published New York, NY The American College of Obstetricians and Gynecologists 01.01.2005
Elsevier Science
Subjects
Adolescent
Adult
Biological and medical sciences
Child
Diethylstilbestrol - adverse effects
Estrogens, Non-Steroidal - adverse effects
Female
Follow-Up Studies
Gynecology. Andrology. Obstetrics
Humans
Leiomyoma - chemically induced
Medical sciences
Middle Aged
Ovarian Cysts - chemically induced
Ovarian Neoplasms - chemically induced
Pregnancy
Prenatal Exposure Delayed Effects
Risk Factors
Uterine Neoplasms - chemically induced
Antineoplastic agent
Agonist
Gynecology
Estrogen
Risk factor
Diethylstilbestrol
Fetus
Benign neoplasm
Sex steroid hormone
Obstetrics
Ovarian hormone
Hormonal receptor
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Summary:OBJECTIVE:To investigate the association between prenatal diethylstilbestrol (DES) exposure and risk of benign gynecologic tumors. METHODS:We conducted a collaborative follow-up study of women with and without documented intrauterine exposure to DES. We compared the incidence of self-reported ovarian cysts, paraovarian cysts, and uterine leiomyomata confirmed by medical record in DES-exposed and unexposed women. RESULTS:A total of 85 cases of uterine leiomyomata and 168 cases of ovarian or paraovarian cysts were confirmed histologically. After adjustment for age, no association was found between prenatal DES exposure and ovarian cysts or uterine leiomyomata. Prenatal DES exposure was positively associated with paraovarian cysts. CONCLUSION:The present results do not support the hypothesis that prenatal DES exposure increases risk of uterine leiomyomata or ovarian cysts. Prenatal DES exposure was associated with an increased risk of paraovarian cysts, but detection bias cannot be ruled out as an explanation of this finding. LEVEL OF EVIDENCE:II-2
ISSN:0029-7844
1873-233X
DOI:10.1097/01.AOG.0000147839.74848.7c