Electrochemical Detection of Zika Virus in Biological Samples: A Step for Diagnosis Point‐of‐care

This work describes an electrochemical genosensor for detection of genomic RNA of Zika virus in real samples of infected patients, using a new platform based on graphite electrodes modified with electrochemically reduced graphene oxide and polytyramine‐conducting polymer. The developed genosensor wa...

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Published inElectroanalysis (New York, N.Y.) Vol. 31; no. 8; pp. 1597 - 1604
Main Authors Moço, Anna C. R., Guedes, Pedro H., Flauzino, José M. R., da Silva, Heliane S., Vieira, Jussara G., Castro, Ana C. H., Gomes, Érica V. R., Tolentino, Fernanda M., Soares, Márcia M. C. N., Madurro, João M., Brito‐Madurro, Ana G.
Format Journal Article
LanguageEnglish
Published 01.08.2019
Subjects
diagnosis
genosensor
nanomaterials
polytyramine
Zika virus
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Summary:This work describes an electrochemical genosensor for detection of genomic RNA of Zika virus in real samples of infected patients, using a new platform based on graphite electrodes modified with electrochemically reduced graphene oxide and polytyramine‐conducting polymer. The developed genosensor was suitable for differentiation between samples of healthy and infected patients with Zika virus by differential pulse voltammetry, detecting up to 0.1 fg/mL (1.72 copies/mL), showing good stability (about 60 days), rapid analysis (about 20 min) and potential for filling the lack of practical diagnostic methods for Zika virus.
ISSN:1040-0397
1521-4109
DOI:10.1002/elan.201900068