Sfrp5 is not essential for axis formation in the mouse
Secreted frizzled related protein (Sfrp) genes encode extracellular factors that can modulate Wnt signaling. During early post‐implantation mouse development Sfrp5 is expressed in the anterior visceral endoderm (AVE) and the ventral foregut endoderm. The AVE is important in anterior–posterior axis f...
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Published in | Genesis (New York, N.Y. : 2000) Vol. 44; no. 12; pp. 573 - 578 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Hoboken
Wiley Subscription Services, Inc., A Wiley Company
01.12.2006
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Subjects | |
Online Access | Get full text |
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Summary: | Secreted frizzled related protein (Sfrp) genes encode extracellular factors that can modulate Wnt signaling. During early post‐implantation mouse development Sfrp5 is expressed in the anterior visceral endoderm (AVE) and the ventral foregut endoderm. The AVE is important in anterior–posterior axis formation and the ventral foregut endoderm contributes to multiple gut tissues. Here to determine the essential role of Sfrp5 in early mouse development we generated Sfrp5‐deficient mice by gene targeting. We report that Sfrp5‐deficient mice are viable and fertile. To determine whether the absence of an axis phenotype might be due to genetic redundancy with Dkk1 in the AVE we generated Sfrp5;Dkk1 double mutant mice. AVE development and primitive streak formation appeared normal in Sfrp5−/−;Dkk1−/− embryos. These results indicate that Sfrp5 is not essential for axis formation or foregut morphogenesis in the mouse and also imply that Sfrp5 and Dkk1 together are not essential for AVE development. genesis 44:573–578, 2006. Published 2006 Wiley‐Liss, Inc. |
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Bibliography: | American Heart Association ark:/67375/WNG-7TF7RSQR-Z This article is a US Government work and, as such, is in the public domain in the United States of America. istex:50AF31292E47BBAF3E0A22B8F97C986802832548 ArticleID:DVG20248 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1526-954X 1526-968X |
DOI: | 10.1002/dvg.20248 |