Elevated risk of papillary thyroid cancer in Korean patients with Hashimoto's thyroiditis

• Published in: Head & neck Vol. 33; no. 5; pp. 691 - 695
• Main Authors: Kim, Kyung Won, Park, Young Joo, Kim, Eun Hye, Park, So Yeon, Park, Do Joong, Ahn, Soon-Hyun, Park, Do Joon, Jang, Hak C., Cho, Bo Youn
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.05.2011; Wiley
• Subjects: Adenocarcinoma, Follicular - epidemiology; Adenocarcinoma, Follicular - pathology; Adenocarcinoma, Follicular - surgery; Autoantibodies - blood; Biological and medical sciences; Carcinoma, Papillary - epidemiology; Carcinoma, Papillary - pathology; Carcinoma, Papillary - surgery; Endocrinopathies; Female; Hashimoto Disease - epidemiology; Hashimoto's thyroiditis; Humans; Iodide Peroxidase - immunology; Male; Malignant tumors; Medical sciences; Middle Aged; Multivariate Analysis; Non tumoral diseases. Target tissue resistance. Benign neoplasms; Otorhinolaryngology. Stomatology; papillary thyroid cancer; Republic of Korea - epidemiology; Risk Factors; Sex Factors; Thyroglobulin - immunology; thyroid cancer; Thyroid Neoplasms - epidemiology; Thyroid Neoplasms - pathology; Thyroid Neoplasms - surgery; Thyroid Nodule - epidemiology; Thyroid Nodule - surgery; thyroid-stimulating hormone; Thyroid. Thyroid axis (diseases); Thyroidectomy; thyrotropin; Thyrotropin - blood; Thyroxine - blood; Republic of Korea; Endocrinopathy; Human; Immunopathology; Stomatology; Thyroid diseases; Autoimmune disease; Korean; Thyroid stimulating hormone; ENT; Malignant tumor; Hashimoto's thyroiditis; thyroid-stimulating hormone; Thyroid cancer; thyrotropin; Hashimoto thyroiditis; papillary thyroid cancer; Risk factor; Cancer
• ISSN: 1043-3074; 1097-0347
• DOI: 10.1002/hed.21518

Background. Hashimoto's thyroiditis (HT) and higher levels of thyroid‐stimulating hormone (TSH) have been proposed as risk factors for papillary thyroid cancer (PTC), but this issue is still being debated. The purpose of this study was whether HT was related to the risk of PTC over TSH. Methods. We enrolled 1329 patients (1028 with PTC, 52 with follicular thyroid cancer, and 249 with benign disease) of 1490 patients who underwent thyroidectomy. Results. The TSH concentration was not different among patients with PTC or benign disease. Our study showed that men (odds ratio [OR] = 1.54; p = .049) and the presence of HT (OR = 2.96; p <.001) increased the risk of PTC. Moreover, HT was associated with multifocal cancer (p = .005) and smaller tumor size (p = .031), but it did not influence the extrathyroidal invasion or nodal metastasis. Conclusion. Clinicians who deal with thyroid nodules should pay particular attention to HT because it is a stronger predictor for PTC than other risk factors. © 2010 Wiley Periodicals, Inc. Head Neck, 2011