Hepatocyte Growth Factor and Primary Systemic Amyloidosis

A 75-year-old-man experienced liver dysfunction and was diagnosed with decompensated liver cirrhosis. His serum hepatocyte growth factor (HGF) was very high (16.24 ng/ml). Because the etiology was unclear, we considered the possibility of amyloidosis. Biopsy of the mucosa of the stomach, duodenum an...

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Bibliographic Details
Published inJournal of UOEH Vol. 43; no. 2; pp. 227 - 233
Main Authors KARASUYAMA, Tsukasa, HONMA, Yuichi, KUMAMOTO, Keiichiro, SHIBATA, Michihiko, WATANABE, Tatsuyuki, SHIMAJIRI, Shohei, ABE, Shintaro, YAMASHITA, Taro, HARADA, Masaru
Format Journal Article
LanguageEnglish
Published The University of Occupational and Environmental Health, Japan 01.06.2021
Subjects
amyloid light-chains
hepatocyte growth factor
hyaluronic acid
primary systemic amyloidosis
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Summary:A 75-year-old-man experienced liver dysfunction and was diagnosed with decompensated liver cirrhosis. His serum hepatocyte growth factor (HGF) was very high (16.24 ng/ml). Because the etiology was unclear, we considered the possibility of amyloidosis. Biopsy of the mucosa of the stomach, duodenum and rectum demonstrated amyloid deposition. From the findings of Congo red staining and immunohistochemical analyses, we made a diagnosis of systemic amyloid light-chain amyloidosis. Unfortunately, the patient died one month after the diagnosis. We considered that serum HGF was useful for the diagnosis and prediction of prognosis of primary systemic amyloidosis.
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ISSN:0387-821X
2187-2864
DOI:10.7888/juoeh.43.227