hepatoprotective action of ten herbal extracts in CCl4 intoxicated liver

• Published in: Phytotherapy research Vol. 19; no. 9; pp. 744 - 749
• Main Authors: Rusu, M.A, Tamas, M, Roman, I, Sabadas, M
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 01.09.2005; Wiley
• Subjects: Animals; Biological and medical sciences; Calendula; Carbon Tetrachloride; CCl4; Chemical and Drug Induced Liver Injury - etiology; Chemical and Drug Induced Liver Injury - prevention & control; Chrysanthemum; Corylus; Echinacea; General pharmacology; intoxicated liver; Liver - drug effects; Liver - enzymology; Male; Medical sciences; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; phytotherapeutic products; Phytotherapy; Plant Components, Aerial; Plant Extracts - administration & dosage; Plant Extracts - pharmacology; Plant Extracts - therapeutic use; Plants, Medicinal; Protective Agents - administration & dosage; Protective Agents - pharmacology; Protective Agents - therapeutic use; Rats; Rats, Wistar; phytotherapeutic products; Rat; Digestive system; Hepatoprotector; Pharmacognosy; Liver; Rodentia; intoxicated liver; Extract; Medicinal plant; Vertebrata; Mammalia; Animal; Plant origin; CCl4; rats
• ISSN: 0951-418X; 1099-1573
• DOI: 10.1002/ptr.1625

The effect of ten phytotherapeutic products on CCl4 intoxicated liver in albino male Wistar rats was investigated. Biochemical parameters, including serum transaminase activity (GPT and GOT), histoenzymological measurements (lactate dehydrogenase, LDH; succinate dehydrogenase, SDH, cytochromoxidase, CyOx; Mg2+‐dependent adenosine triphosphatase, ATP‐ase) and histochemical (Sudan black) and histological examinations (haematoxylin‐eosin staining) of the liver were investigated. Some positive effects such as the reduction of hepatocytolysis and steatosis, and a return to normal values of the activity of some enzymes in the following plants: Chrysanthemum balsamita, Echinacea pallida, Calendula officinalis and Corylus avelana were obtained. Copyright © 2005 John Wiley & Sons, Ltd.