Method specificity of the auscultatory estimates of the inodilatory reduction of diastolic blood pressure based on Korotkoff IV and V criteria

• Published in: British journal of clinical pharmacology Vol. 39; no. 5; pp. 485 - 490
• Main Author: De, Mey C
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.05.1995
• Subjects: Administration, Oral; Adult; Blood Pressure - drug effects; Blood Pressure - physiology; Blood Pressure Determination; Cardiotonic Agents - administration & dosage; Cardiotonic Agents - pharmacology; Cardiovascular Agents - administration & dosage; Cardiovascular Agents - pharmacology; Celiprolol - administration & dosage; Celiprolol - pharmacology; Cross-Over Studies; Eating - physiology; Epinephrine - administration & dosage; Epinephrine - pharmacology; Heart Rate - drug effects; Heart Rate - physiology; Humans; Imidazoles - administration & dosage; Imidazoles - pharmacology; Infusions, Intravenous; Isoproterenol - administration & dosage; Isoproterenol - pharmacology; Male; Phosphodiesterase Inhibitors - administration & dosage; Phosphodiesterase Inhibitors - pharmacology; Pyridazines - administration & dosage; Pyridazines - pharmacology; Reproducibility of Results; Vasodilator Agents - administration & dosage; Vasodilator Agents - pharmacology
• ISSN: 0306-5251; 1365-2125
• DOI: 10.1111/j.1365-2125.1995.tb04484.x

1. Non‐invasive measurements of blood pressure (BP) are method‐specific estimates of actual blood pressure. The agreement of the auscultatory Korokoff V ('disappearance' of sound, kv) and Korokoff IV ('sound muffling' kiv) cut‐off points in measuring diastolic blood pressure (DBP) was evaluated in healthy subjects in the presence of various controlled inodilatory interventions. 2. Eating (n = 8), 10 min i.v. infusion of 1 microgram min‐1 isoprenaline and adrenaline (n = 12), p.o. administration of 40 mg of the PDE‐III inhibitors isomazole and meribendan (n = 18) and p.o. administration of 1200 mg celiprolol (n = 15) caused evident chrono‐inodilatory responses: average HR increases of 7, 19, 10, 17, 17 and 8 beats min‐1, estimated CO increases of 1.6, 4.5, 2.3, 1.9, 2.6 and 1.8 1 min‐1 and average shortening of QS2c of 18, 41, 8, 37, 42 and 9 ms for food, isoprenaline, adrenaline, isomazole, meribendan and celiprolol, respectively. 3. In general, there was good agreement between DBPkV and DBPkIV measurements before the administration of the inodilatory treatments (bias DBPkV‐DBPkIV: 1‐ 2 mm Hg) but the extent of inodilatory DBP reduction (‐8, ‐6, ‐10, ‐2, ‐ 7 and ‐8 mm Hg according to DBPkIV for food, isoprenaline, adrenaline, isomazole, meribendan and celiprolol, respectively) was substantially overestimated when based on Korotkoff‐V rather than ‐IV (bias DBPkV‐ DBPkIV in estimating the inodilatory effect on DBP: ‐8, ‐12, 1, ‐13, ‐ 12 and ‐7 mm Hg for food, isoprenaline, adrenaline, isomazole, meribendan and celiprolol, respectively).