QT Dispersion is Increased in Diabetic Patients with Foot Ulcer

• Published in: Journal of Atherosclerosis and Thrombosis Vol. 6; no. 1; pp. 13 - 17
• Main Authors: Imano, Eiichi, Yoshioka, Rieko, Nakatani, Yoshihisa, Arai, Katsumi, Motomura, Masaaki, Kanda, Tsutomu, Yamasaki, Yoshimitsu, Hori, Masatsugu
• Format: Journal Article
• Language: English
• Published: Japan Japan Atherosclerosis Society 2000
• Subjects: Aged; Arteriosclerosis; Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - physiopathology; Diabetic Foot - physiopathology; Diabetic neuropathy; Diabetic ulcer; Electrophysiology; Heart Ventricles - physiopathology; Humans; Middle Aged; QT dispersion
• ISSN: 1340-3478; 1880-3873
• DOI: 10.5551/jat1994.6.13

QT dispersion, a measure of inhomogenous ventricular repolarization, was measured in diabetic patients with foot ulcer. We recruited 75 patients with non-insulin-dependent diabetes mellitus : patients with neuropathic ulcer (n=15, NU group), with ischemic ulcer (n=20, IU group), with previous myocardial infarction (n=20, MI group) and without any diabetic microangiopathies (n=20, DC group). We also studied normal control subjects (n=15, NC group). The interlead variability of rate-corrected OT interval (QTc dispersion) was calculated. QTc interval in the MI group was significantly higher than that in the NC or DC but showed no difference in the NU and IU groups. QTc dispersion in the IU (54±15 msec) as well as MI (60±21 msec) group were significantly higher than the NC (36±18 msec) or DC group (39±14 msec). This may be due to complicated coronary artery disease in the IU group. Furthermore, QTc dispersion was also increased (49±14 msec) in the NU group in which cardiac autonomic nervous dysfunction was suggested. Patients with both types of diabetic ulcer demonstrated increased QT dispersion due to atherosclerosis or neurological disorder.