Developmental genes and cancer in children

Childhood tumours are associated with congenital abnormalities suggesting that disruption of normal developmental processes may be linked with oncogenesis. Genetic and environmental exposures may combine to disrupt critical epigenetic processes during development, thus affecting gene‐related signall...

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Bibliographic Details
Published inPediatric Blood & Cancer Vol. 52; no. 7; pp. 755 - 760
Main Author Moore, Sam W.
Format Journal Article
LanguageEnglish
Published Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.07.2009
Subjects
Adolescent
cancer
Child
Child, Preschool
children
development
genes
Genes, Developmental - physiology
Humans
Infant
Neoplasms - genetics
Neoplasms - metabolism
Neoplasms - pathology
oncogenes
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Summary:Childhood tumours are associated with congenital abnormalities suggesting that disruption of normal developmental processes may be linked with oncogenesis. Genetic and environmental exposures may combine to disrupt critical epigenetic processes during development, thus affecting gene‐related signalling pathways and cellular function. This review examines the role of critical genes and processes regulating development such as the polycomb family and sonic hedgehog (SHH) as well as the Wnt signalling pathways and epigenetic variations (Snf5), methylation and loss of heterozygosity in controlling homeotic gene transcription and intracellular chromatin structure. The developmental and perinatal periods appears important as a window of opportunity for cancer research. Pediatr Blood Cancer 2009;52:755–760. © 2009 Wiley‐Liss, Inc.
Bibliography:istex:32ECDCE9EA3A1960A6FFDCB6CA7932F724094B56
ark:/67375/WNG-F4K22CCS-3
ArticleID:PBC21831
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ObjectType-Review-1
ISSN:1545-5009
1545-5017
1096-911X
DOI:10.1002/pbc.21831