Repeated courses of granulocyte colony-stimulating factor in amyotrophic lateral sclerosis: Clinical and biological results from a prospective multicenter study

• Published in: Muscle & nerve Vol. 43; no. 2; pp. 189 - 195
• Main Authors: Chiò, Adriano, Mora, Gabriele, Bella, Vincenzo La, Caponnetto, Claudia, Mancardi, Gianluigi, Sabatelli, Mario, Siciliano, Gabriele, Silani, Vincenzo, Corbo, Massimo, Moglia, Cristina, Calvo, Andrea, Mutani, Roberto, Rutella, Sergio, Gualandi, Francesca, Melazzini, Mario, Scimè, Rosanna, Petrini, Mario, Bondesan, Paola, Garbelli, Silvia, Mantovani, Stefania, Bendotti, Caterina, Tarella, Corrado
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.02.2011; Wiley
• Subjects: Adult; Aged; amyotrophic lateral sclerosis; Amyotrophic Lateral Sclerosis - blood; Amyotrophic Lateral Sclerosis - cerebrospinal fluid; Amyotrophic Lateral Sclerosis - drug therapy; Biological and medical sciences; clinical trial; Cytokines - blood; Cytokines - cerebrospinal fluid; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Disability Evaluation; Female; Follow-Up Studies; granulocyte colony-stimulating factor; Granulocyte Colony-Stimulating Factor - blood; Granulocyte Colony-Stimulating Factor - cerebrospinal fluid; Granulocyte Colony-Stimulating Factor - therapeutic use; hematopoietic stem cells; Humans; Male; Medical sciences; Middle Aged; neuroinflammation; Neurology; Pilot Projects; Prospective Studies; Surveys and Questionnaires; Treatment Outcome; Human; Nervous system diseases; Multicenter study; Cytokine; Amyotrophic lateral sclerosis; Cerebrospinal fluid; granulocyte colony-stimulating factor; Protein; Transitory; Prospective; Granulocyte colony stimulating factor; Treatment; neuroinflammation; Central nervous system disease; Clinical trial; Serum; Degenerative disease; Safety; hematopoietic stem cells; Spinal cord disease
• ISSN: 0148-639X; 1097-4598
• DOI: 10.1002/mus.21851

Granulocyte colony‐stimulating factor (G‐CSF) induces a transient mobilization of hematopoietic progenitor cells from bone marrow to peripheral blood. Our aim was to evaluate safety of repeated courses of G‐CSF in patients with amyotrophic lateral sclerosis (ALS), assessing disease progression and changes in chemokine and cytokine levels in serum and cerebrospinal fluid (CSF). Twenty‐four ALS patients entered an open‐label, multicenter trial in which four courses of G‐CSF and mannitol were administered at 3‐month intervals. Levels of G‐CSF were increased after treatment in the serum and CSF. Few and transitory adverse events were observed. No significant reduction of the mean monthly decrease in ALSFRS‐R score and forced vital capacity was observed. A significant reduction in CSF levels of monocyte chemoattractant protein‐1 (MCP‐1) and interleukin‐17 (IL‐17) was observed. G‐CSF treatment was safe and feasible in a multicenter series of ALS patients. A decrease in the CSF levels of proinflammatory cytokines MCP‐1 and IL‐17 was found, indicating a G‐CSF–induced central anti‐inflammatory response. Muscle Nerve 43: 189–195, 2011