Synthesis of 3,3-Dihalo-2-oxindoles from 2-Substituted Indoles via Halogenation-Decarboxylation/Desulfonamidation-Oxidation Process

A novel one‐pot reaction which combines halogenation, decarboxylation/desulfonamidation with oxidation has been developed. Diverse valuable 3,3‐dihalo‐2‐oxindole compounds can be produced rapidly and safely with isolated yields of up to 98% under mild conditions.

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Bibliographic Details
Published inAdvanced synthesis & catalysis Vol. 358; no. 24; pp. 3938 - 3942
Main Authors Jiang, Xiaojian, Zhang, Feng, Yang, Junjie, Yu, Pei, Yi, Peng, Sun, Yewei, Wang, Yuqiang
Format Journal Article
LanguageEnglish
Published WEINHEIM Blackwell Publishing Ltd 22.12.2016
Wiley
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Subjects
3,3-dihalo-2-oxindoles
3-dihalo-2-oxindoles
Chemistry
Chemistry, Applied
Chemistry, Organic
Decarboxylation
desulfonamidation
Halogenation
Indoles
Oxidation
Physical Sciences
Science & Technology
3,3-dihalo-2-oxindoles
DECARBOXYLATIVE HALOGENATION
POLYMERS
SELECTIVE OXIDATION
decarboxylation
oxidation
INDOLECARBOXYLIC ACIDS
halogenation
ALCOHOLS
N-BROMOSUCCINIMIDE
desulfonamidation
INHIBITORS
DERIVATIVES
EFFICIENT
CHLOROSUCCINIMIDE
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Summary:A novel one‐pot reaction which combines halogenation, decarboxylation/desulfonamidation with oxidation has been developed. Diverse valuable 3,3‐dihalo‐2‐oxindole compounds can be produced rapidly and safely with isolated yields of up to 98% under mild conditions.
Bibliography:National Natural Science Foundation of China - Grant No. 21502068
ark:/67375/WNG-RC7RCLBC-W
istex:EDCF4FF8DBC24E0ADFF0972E5BA2EE73C06E6A23
ArticleID:ADSC201600771
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.201600771