Silver‐Catalyzed Radical Cascade Cyclization of Unactivated Alkenes towards Cyclopenta[c]quinolines

A convenient radical cascade cyclization of aniline‐linked 1,7‐enynes with 1,3‐dicarbonyl compounds was developed to synthesize cyclopenta[c]quinolines in the presence of AgNO3/K2S2O8. A wide range of cyclopenta[c]quinolines were prepared in moderate to excellent yields.

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Bibliographic Details
Published inAdvanced synthesis & catalysis Vol. 361; no. 19; pp. 4483 - 4488
Main Authors Sun, Kai, Si, Ya‐Feng, Chen, Xiao‐Lan, Lv, Qi‐Yan, Jiang, Nan, Wang, Shan‐Shan, Peng, Yu‐Yu, Qu, Ling‐Bo, Yu, Bing
Format Journal Article
LanguageEnglish
Published WEINHEIM Wiley 08.10.2019
Subjects
1,3-Dicarbonyl compound
Chemistry
Chemistry, Applied
Chemistry, Organic
Cyclopenta[c]quinolines
Physical Sciences
Radical cascade reaction
Science & Technology
Unactivated alkenes
1,7-ENYNES
Cyclopenta[c]quinolines
ONE-POT SYNTHESIS
ANNULATION
ACIDS
ISOCYANIDES
EFFICIENT SYNTHESIS
3-Dicarbonyl compound
1
Unactivated alkenes
Radical cascade reaction
BOND
ACCESS
1,N-ENYNES
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Summary:A convenient radical cascade cyclization of aniline‐linked 1,7‐enynes with 1,3‐dicarbonyl compounds was developed to synthesize cyclopenta[c]quinolines in the presence of AgNO3/K2S2O8. A wide range of cyclopenta[c]quinolines were prepared in moderate to excellent yields.
Bibliography:Kai Sun and Ya‐Feng Si contributed equally.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.201900691