Conodurine, conoduramine, and ervahanine derivatives from Tabernaemontana corymbosa

• Published in: Phytochemistry (Oxford) Vol. 63; no. 5; pp. 625 - 629
• Main Authors: Kam, Toh-Seok, Sim, Kooi-Mow
• Format: Journal Article
• Language: English
• Published: OXFORD Elsevier Ltd 01.07.2003; Elsevier
• Subjects: Alkaloids - chemistry; Alkaloids - isolation & purification; Apocynaceae; Biochemistry & Molecular Biology; Biological and medical sciences; Bisindole alkaloids; Bridged-Ring Compounds - chemistry; Bridged-Ring Compounds - isolation & purification; Chemical constitution; Fundamental and applied biological sciences. Psychology; Indole Alkaloids - chemistry; Indole Alkaloids - isolation & purification; Life Sciences & Biomedicine; Magnetic Resonance Spectroscopy; Molecular Structure; Plant physiology and development; Plant Sciences; Science & Technology; Tabernaemontana - chemistry; Tabernaemontana species; Apocynaceae; Bisindole alkaloids; Tabernaemontana species; DIMERIC INDOLE ALKALOIDS; A-D; bisindole alkaloids; MALAYAN TABERNAEMONTANA; Alkaloid; Molecular structure; Dicotyledones; Angiospermae; Bark; Isolation; Spermatophyta; Plant leaf; Indole derivatives
• ISSN: 0031-9422; 1873-3700
• DOI: 10.1016/S0031-9422(03)00087-6

Four bisindole alkaloids, viz., 19′( S)-hydroxyconodurine, conodurinine, 19′( S)-hydroxyconoduramine, and 19′( S)-hydroxyervahanine A, in addition to conodurine and ervahanine A, were obtained from the leaf and stem-bark extracts of Tabernaemontana corymbosa. The structures of the new alkaloids were determined using NMR and MS analysis. Four bisindole alkaloids (e.g., conodurinine) were obtained from the leaf and stem-bark extracts of Tabernaemontana corymbosa.