LMP7 polymorphism in Japanese patients with sarcoidosis and Behçet's disease

To evaluate the influence of the MHClinked LMP7 gene on disease susceptibility in HLA class I and class II-associated diseases, the distribution of LMP7 alleles was determined using the PCR-RFLP method in 69 Japanese patients with Behçet's disease, 65 patients with sarcoidosis, and 100 unrelate...

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Published inHuman immunology Vol. 51; no. 2; pp. 103 - 105
Main Authors Ishihara, Mami, Ohno, Shigeaki, Mizuki, Nobuhisa, Yamagata, Naomi, Ishida, Takako, Naruse, Taeko, Ando, Asako, Inoko, Hidetoshi
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.12.1996
Subjects
Alleles
Behcet Syndrome - genetics
Cysteine Endopeptidases
Disease Susceptibility
HLA-D Antigens - genetics
Humans
Japan
Linkage Disequilibrium - immunology
Major Histocompatibility Complex - genetics
Multienzyme Complexes
Polymorphism, Genetic - genetics
Proteasome Endopeptidase Complex
Proteins - genetics
Sarcoidosis - genetics
Japan
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Summary:To evaluate the influence of the MHClinked LMP7 gene on disease susceptibility in HLA class I and class II-associated diseases, the distribution of LMP7 alleles was determined using the PCR-RFLP method in 69 Japanese patients with Behçet's disease, 65 patients with sarcoidosis, and 100 unrelated healthy controls. No differences were found between either of the patient groups and the healthy control group, indicating that LMP7 allelic variation may not contribute to the pathogenesis of either Behçet's disease or sarcoidosis. We also analyzed linkage disequilibria between LMP7 and HLA class II alleles in Japanese populations.
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ISSN:0198-8859
1879-1166
DOI:10.1016/S0198-8859(96)00226-1