Differential modulation of μ- and δ-opioid antinociception by neuropeptide FF receptors in young mice

• Published in: Neuropeptides (Edinburgh) Vol. 31; no. 1; pp. 1 - 7
• Main Authors: Desprat, C, Zajac, J.-M
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.02.1997
• Subjects: Age Factors; Analgesics, Opioid - pharmacology; Animals; Enkephalin, Ala-MePhe-Gly; Enkephalins - pharmacology; Male; Mice; Mice, Inbred Strains; Morphine - pharmacology; Naltrexone - analogs & derivatives; Naltrexone - pharmacology; Narcotic Antagonists - pharmacology; Neuropeptides - pharmacology; Nociceptors - drug effects; Nociceptors - physiology; Oligopeptides - pharmacology; Receptors, Neuropeptide - metabolism; Receptors, Opioid, delta - agonists; Receptors, Opioid, delta - antagonists & inhibitors; Receptors, Opioid, delta - metabolism; Receptors, Opioid, mu - agonists; Receptors, Opioid, mu - antagonists & inhibitors; Receptors, Opioid, mu - metabolism

The ability of neuropeptide FF (NPFF) to modulate μ- and δ-opioid-induced analgesia by intracerebroventricular administration was compared in adults and 14-day-old mice. In adults, opioid-induced analgesia was predominantly mediated by μ-receptors whereas μ- and δ-receptors were equally involved in...