Differential modulation of μ- and δ-opioid antinociception by neuropeptide FF receptors in young mice

The ability of neuropeptide FF (NPFF) to modulate μ- and δ-opioid-induced analgesia by intracerebroventricular administration was compared in adults and 14-day-old mice. In adults, opioid-induced analgesia was predominantly mediated by μ-receptors whereas μ- and δ-receptors were equally involved in...

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Published inNeuropeptides (Edinburgh) Vol. 31; no. 1; pp. 1 - 7
Main Authors Desprat, C, Zajac, J.-M
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier Ltd 01.02.1997
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Summary:The ability of neuropeptide FF (NPFF) to modulate μ- and δ-opioid-induced analgesia by intracerebroventricular administration was compared in adults and 14-day-old mice. In adults, opioid-induced analgesia was predominantly mediated by μ-receptors whereas μ- and δ-receptors were equally involved in pups. An NPFF analog, 1DMe, reduced the analgesic effect of DAGO and [D.Ala 2]deltorphin-I, μ and δ selective agonists respectively. However, a high dose of 1DMe (22 nmol) increased both morphine and [D.Ala 2]deltorphin-I-induced analgesia. Dose—response curves for 1DMe in the presence of naltrindole or naltrexone, δ- and μ-opioid selective antagonists respectively, indicate that 1DMe preferentially reversed μ-receptor-mediated but increased δ-receptor-mediated analgesia. These findings demonstrate differences in control of μ- and δ-induced analgesia by NPFF receptors.
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ISSN:0143-4179
1532-2785
DOI:10.1016/S0143-4179(97)90010-X