Antiulcer activity of Sapindus saponaria L. in the rat

• Published in: Journal of ethnopharmacology Vol. 82; no. 1; pp. 41 - 44
• Main Authors: Meyer Albiero, Adriana L, Aboin Sertié, Jayme Antonio, Bacchi, Elfriede Marianne
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 01.09.2002; Elsevier
• Subjects: Administration, Oral; Animals; Anti-Ulcer Agents - therapeutic use; Anti-Ulcer Agents - toxicity; Antiulcer activity; Biological and medical sciences; Dose-Response Relationship, Drug; Ethanol; Female; Gastric Acid - metabolism; General pharmacology; Medical sciences; Organ Size; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Phytotherapy; Plant Extracts - therapeutic use; Plant Extracts - toxicity; Rats; Rats, Wistar; Sapindaceae; Sapindus; Sapindus saponaria L; Stomach - drug effects; Stomach - pathology; Stomach Ulcer - drug therapy; Stomach Ulcer - pathology; Stomach Ulcer - physiopathology; Sapindus saponaria L; Antiulcer activity; Sapindaceae; Rat; Antiulcer agent; Medicinal plant; Endocrine secretion; Dicotyledones; Antisecretory agent; Angiospermae; pH; Mechanism of action; Stomach; Fruit; Digestive system; Pharmacognosy; Rodentia; Cimetidine; Oral administration; Plant leaf; Stress; Vertebrata; Mammalia; Animal; Plant origin; Spermatophyta; Antiacid; Comparative study; Gastric juice
• ISSN: 0378-8741; 1872-7573
• DOI: 10.1016/S0378-8741(02)00094-6

Extracts of leaves and fruits of Sapindus saponaria L. were orally administered to rats and the parameters of gastric secretion (volume, pH and acidity) were evaluated after pylorus ligature. The inhibitory effect of the extracts on lesions induced by stress was compared to that of cimetidine. The volume and concentration of hydrochloric acid were reduced after oral administration of the extracts. A significant reduction of the lesion index was observed in the acute assays. No significant alteration in body or organ weight was detected in animals treated orally for 30 days with the extracts. These results suggest that S. saponaria fruits have an anti-gastric ulcer potential.