Phycomyces and the biology of light and color

• Published in: FEMS microbiology reviews Vol. 25; no. 5; pp. 503 - 512
• Main Author: Cerdá-Olmedo, Enrique
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier B.V 01.12.2001; Blackwell
• Subjects: Action of physical and chemical agents on bacteria; Bacteriology; Behavourial genetics; Biological and medical sciences; Biological treatment of gaseous effluents; Biotechnology; Carotenoids - metabolism; Environment and pollution; Fundamental and applied biological sciences. Psychology; Genes, Fungal; Industrial applications and implications. Economical aspects; Light; Microbiology; Mutation; Photobiology; Phototropism; Phycomyces; Phycomyces - genetics; Phycomyces - metabolism; Phycomyces - physiology; Phycomyces blakesleeanus; Sensory transduction; Vision, Ocular - genetics; Phycomyces blakesleeanus; Photobiology; Sensory transduction; Behavourial genetics; Phycomyces; Prototype; Carotene; Growth; Insecta; Drosophila; Use; Phycomycetes; Color; Biology; Drosophilidae; Fungi; Sensitivity; Arthropoda; Light; Manipulation; Development; Genetics; Invertebrata; Diptera; Thallophyta; Adaptation
• ISSN: 0168-6445; 1574-6976
• DOI: 10.1016/S0168-6445(01)00064-X

Phycomyces has been in the laboratories for about 140 years, sometimes following trends and fashions, but often anticipating them. Researchers have been attracted by the sensitive and precise responses of Phycomyces to light and other stimuli, coupled with easy manipulations and good adaptation to laboratory life. It is a simple prototype of the many organisms that use light as a source of information but not as a significant source of energy. Growth, development, genetics, and carotene production have been other subjects of pioneering research. Phycomyces was the second organism, after us, known to require a vitamin. It was one of the first organisms in the research on spontaneous mutants and the second, after Drosophila, in which mutations were induced artificially. It was used to coin the concept and the name of heterokaryosis. Phycomyces heterokaryons offer unique experimental possibilities, for instance in the study of gene function in vivo and the causes of cell death. An overall impression of parsimony and combinatorial gene usage arises from the genetic analysis of the complex functions of this fungus. The main subjects of recent attention have been the various reactions to light, gravitropism, and some aspects of metabolism, particularly the production of carotene. Interest in Phycomyces is slacking because of the repeated failures at transforming it stably with exogenous DNA.