Increased urinary excretion of renal enzymes in idiopathic calcium oxalate nephrolithiasis

Urinary excretion of gamma-glutamyl transpeptidase, angiotensin I converting enzyme, beta-galactosidase and N-acetyl-beta-glucosaminidase was evaluated in 30 patients with idiopathic calcium oxalate urolithiasis. Higher than normal values were observed and the excretory enzyme pattern suggested tubu...

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Bibliographic Details
Published inThe Journal of urology Vol. 129; no. 6; p. 1161
Main Authors Baggio, B, Gambaro, G, Ossi, E, Favaro, S, Borsatti, A
Format Journal Article
LanguageEnglish
Published United States 01.06.1983
Subjects
Acetylglucosaminidase - urine
Adult
Animals
beta-Galactosidase - urine
Calcium Oxalate
Female
gamma-Glutamyltransferase - urine
Humans
Kidney - enzymology
Kidney Calculi - enzymology
Male
Middle Aged
Peptidyl-Dipeptidase A - urine
Rats
Rats, Inbred Strains
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Summary:Urinary excretion of gamma-glutamyl transpeptidase, angiotensin I converting enzyme, beta-galactosidase and N-acetyl-beta-glucosaminidase was evaluated in 30 patients with idiopathic calcium oxalate urolithiasis. Higher than normal values were observed and the excretory enzyme pattern suggested tubular damage in patients with stones. A parallel study in the rat showed that an oxalate surcharge can promote increased urinary excretion of these enzymes. It is known that urothelium injury may enhance crystal adhesion. If the damage is primary it may be viewed as a promoting factor. If it is secondary it may be considered a factor capable of increasing salt precipitation.
ISSN:0022-5347
DOI:10.1016/S0022-5347(17)52619-1