Antimicrobial agents

Antimicrobial agents active against multi-resistant Gram-positive bacteria are considered to be of major commercial potential. Commercially viable agents that have been included in recent successful trials include the streptogramins, novel glycopeptides, oxazolidinones and potent quinolones. Cationi...

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Bibliographic Details
Published inCurrent opinion in chemical biology Vol. 1; no. 2; pp. 169 - 175
Main Author Bush, Karen
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.08.1997
Subjects
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
Drug Resistance, Multiple
Gram-Positive Bacteria - drug effects
Humans
MRSA methicillin-resistant Staphylococcus aureus
PRS penicillin-resistant streptococci
MIC 90 MIC for 90% of organisms tested
MIC minimum inhibitory concentration
VRE vancomycin-resistant enterococci
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Summary:Antimicrobial agents active against multi-resistant Gram-positive bacteria are considered to be of major commercial potential. Commercially viable agents that have been included in recent successful trials include the streptogramins, novel glycopeptides, oxazolidinones and potent quinolones. Cationic peptides have generated much interest, but their utility as successful drug candidates remains questionable. Novel compound classes for possible exploitation include non-β-lactam β-lactamaseinhibitors, inhibitors of lipid A biosynthesis and tRNA synthetase inhibitors.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ISSN:1367-5931
1879-0402
DOI:10.1016/S1367-5931(97)80006-3