In vitro synergy testing of levofloxacin, ofloxacin, and ciprofloxacin in combination with aztreonam, ceftazidime, or piperacillin against Pseudomonas aeruginosa

• Published in: Diagnostic microbiology and infectious disease Vol. 42; no. 1; pp. 75 - 78
• Main Authors: Pendland, Susan L., Messick, Chad R., Jung, Rose
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 2002; Elsevier
• Subjects: Anti-Infective Agents - pharmacology; Antibacterial agents; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antiseptics; Aztreonam - pharmacology; Biological and medical sciences; Ceftazidime - pharmacology; Cephalosporins - pharmacology; Ciprofloxacin - pharmacology; Drug Synergism; Humans; Lactams - pharmacology; Levofloxacin; Medical sciences; Microbial Sensitivity Tests; Monobactams - pharmacology; Ofloxacin - pharmacology; Penicillins - pharmacology; Pharmacology. Drug treatments; Piperacillin - pharmacology; Pseudomonas aeruginosa - drug effects; Pseudomonadales; Levofloxacin; β-Lactams; Ofloxacin; Monobactam derivatives; Penicillin derivatives; Cephalosporin derivatives; Fluoroquinolone derivatives; Azetidine derivatives; Piperacillin; Aztreonam; Bacteria; Pseudomonadaceae; Pseudomonas aeruginosa; Ciprofloxacin; Ceftazidime; Quinolone derivatives
• ISSN: 0732-8893; 1879-0070
• DOI: 10.1016/S0732-8893(01)00312-1

The synergistic potential of levofloxacin, ofloxacin and ciprofloxacin combined with aztreonam, ceftazidime, or piperacillin was compared using 24 strains of Pseudomonas aeruginosa with varying susceptiblity profiles. Levofloxacin and ciprofloxacin demonstrated similar in vitro activity, with ofloxacin demonstrating less activity compared to the other agents. Predominately additive effects were seen with all combinations, with no significant differences detected between the fluoroquinolone agents.