Use of an impinging jet for dispersion of dry powder inhalation aerosols

• Published in: International journal of pharmaceutics Vol. 275; no. 1; pp. 123 - 131
• Main Authors: Wang, Zhaolin, Lange, Carlos F., Finlay, Warren H.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 04.05.2004; Elsevier
• Subjects: Administration, Inhalation; Aerosol; Aerosols; Albuterol - administration & dosage; Albuterol - chemistry; Biological and medical sciences; Cascade impactor; Chemical Phenomena; Chemistry, Physical; Drug Delivery Systems - instrumentation; Drug Delivery Systems - methods; Dry powder inhaler; General pharmacology; Impinging jet; Lactose; Medical sciences; Nebulizers and Vaporizers; Particle Size; Pharmaceutical technology. Pharmaceutical industry; Pharmacology. Drug treatments; Powder deagglomeration; Powder dispersion; Powders - administration & dosage; Powders - chemistry; Dry powder inhaler; Impinging jet; Powder dispersion; Cascade impactor; Aerosol; Powder deagglomeration; Use; Aerosols; Dispersion; Powder; Inhalation
• ISSN: 0378-5173; 1873-3476
• DOI: 10.1016/j.ijpharm.2004.01.029

The dispersion of Ventodisk ® (salbutamol sulphate with lactose) from different drug reservoirs by an air jet at normal impingement is examined experimentally. The effect on dispersion efficiency of jet velocity, nozzle location, reservoir size and shape, and the loaded dose is investigated for possible design of new dosing methods or inhalers. Results show that higher jet velocity (as high as feasible), lower drug loading (2 mg or smaller), a cylindrical hole reservoir (6 mm in diameter and 3 mm in depth) and a medium distance (approximately 5 jet diameters) from the nozzle to the reservoir yield optimum dispersion. The dispersed fine particle dose improves by a factor of 2–3 times between optimized conditions and poor conditions.