Does the application of gadolinium-DTPA have an impact on magnetic resonance phase contrast velocity measurements? Results from an in vitro study

• Published in: European journal of radiology Vol. 44; no. 1; pp. 65 - 69
• Main Authors: Heverhagen, J.T, Hoppe, M, Klose, K.-J, Wagner, H.-J
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 01.10.2002; Elsevier Science
• Subjects: Biological and medical sciences; Blood Flow Velocity; Constriction, Pathologic - diagnosis; Constriction, Pathologic - physiopathology; Contrast Media - administration & dosage; Experimental; Gadolinium DTPA - administration & dosage; Investigative techniques, diagnostic techniques (general aspects); Magnetic resonance; Magnetic Resonance Angiography; Medical sciences; Miscellaneous. Technology; Models, Biological; Phantoms; Phase imaging; Radiodiagnosis. Nmr imagery. Nmr spectrometry; Vascular; Vascular; Phase imaging; Magnetic resonance; Experimental; Phantoms; Gadolinium compound; Experimental study; Nuclear magnetic resonance imaging; In vitro; Phase contrast; Medical imagery; Influence; Flow velocity; Hemodynamics; Technique; NMR angiography; Contrast media; Test object
• ISSN: 0720-048X; 1872-7727
• DOI: 10.1016/S0720-048X(01)00425-9

Introduction/objective: To evaluate the potential influence of various concentrations of gadolinium (Gd)-DTPA on magnetic resonance phase contrast (MR PC) velocimetry. Material and methods: Imaging was done with a 1.0 T scanner using a standard Flash 2D sequence and a circular polarized extremity coil. In a validated flow phantom with a defined 75% area stenosis different concentrations of Gd-DTPA, diluted in a 10:1 water–yogurt mixture, MR PC measurements were correlated with a Doppler guide wire as gold standard. Results: MR PC measurements correlated well with the Doppler derived data ( r=0.99; P<0.01; maximum pre-stenotic velocity: 21.6±0.5 cm/s; maximum intra-stenotic velocity: 81.7±0.6 cm/s). Following Gd-DTPA administration no significant ( P>0.05; Student's t-test) flow measurement changes were noted (maximum pre-stenotic velocity: 21.3±1.3 cm/s; maximum intra-stenotic velocity: 84.0±3.6 cm/s). However, delineation of the perfused lumen was enhanced after the application of Gd-DTPA. Discussions and conclusion: The application of Gd-DTPA does not affect MR PC velocimetry. However, the application of contrast media allowed a more accurate vessel segmentation. MR PC measurements can be reliably carried out after application of Gd-DTPA.