Interleukin 12 ( IL12B) and Interleukin 12 Receptor ( IL12RB1) Gene Polymorphisms in Rheumatoid Arthritis

The aim of this study was to assess the possible association between the IL12B and the IL12RB1 gene polymorphisms and the systemic autoimmune disease rheumatoid arthritis (RA). Our study population consisted of 545 patients with RA and 393 healthy subjects. All the individuals were of white Spanish...

Full description

Saved in:
Bibliographic Details
Published inHuman Immunology Vol. 66; no. 6; pp. 710 - 714
Main Authors Orozco, Gisela, González-Gay, Miguel A., Paco, Laura, López-Nevot, Miguel A., Guzmán, Manuel, Pascual-Salcedo, Dora, Balsa, Alejandro, Martín, Javier
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.06.2005
Subjects
3' Untranslated Regions
Arthritis, Rheumatoid - genetics
Arthritis, Rheumatoid - physiopathology
Female
Genetic Predisposition to Disease
Genotype
Humans
interleukin 12
interleukin 12 receptor
Interleukin-12 - genetics
Male
polymorphism
Polymorphism, Genetic
Promoter Regions, Genetic
Receptors, Interleukin - genetics
Receptors, Interleukin-12
rheumatoid arthritis
Sex Factors
susceptibility
Spain
interleukin 12
interleukin 12 receptor
polymorphism
susceptibility
rheumatoid arthritis
Online AccessGet full text

Cover

More Information
Summary:The aim of this study was to assess the possible association between the IL12B and the IL12RB1 gene polymorphisms and the systemic autoimmune disease rheumatoid arthritis (RA). Our study population consisted of 545 patients with RA and 393 healthy subjects. All the individuals were of white Spanish origin. Genotyping of the IL12B (IL12Bpro and IL12B 3′ untranslated region) and IL12RB1 (641A→G, 1094T→C, and 1132G→C) polymorphisms was performed by polymerase chain reaction-restriction fragment length polymorphism and polymerase chain reaction-fluorescent methods. No statistically significant differences in the distribution of the IL12B and the IL12RB1 genotypes and alleles between patients with RA and control subjects were observed. In addition, no association was found between the above-mentioned polymorphisms with any of the demographic and clinical parameters tested in patients with RA. These results suggest that IL12B and IL12RB1 genes may not play a relevant role in the susceptibility or severity of RA in the Spanish population.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0198-8859
1879-1166
1365-2567
DOI:10.1016/j.humimm.2005.02.004