Antifungal sordarins. Synthesis and structure–activity relationships of 3′,4′-Fused dioxolane and dioxane derivatives

A number of novel 3′,4′-fused dioxolane and dioxane sordarin derivatives were synthesised for structure–activity relationship studies. Many of these derivatives exhibit high activity against Candida spp. and Cryptococcus neoformans. A number of novel 3′,4′-fused sordarin derivatives were synthesised...

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Bibliographic Details
Published inBioorganic & medicinal chemistry letters Vol. 12; no. 2; pp. 121 - 124
Main Authors Bueno, José M, Cuevas, Juan C, Fiandor, José M, Garcı́a-Ochoa, Silvestre, Gómez de las Heras, Federico
Format Journal Article
LanguageEnglish
Published Oxford Elsevier Ltd 21.01.2002
Elsevier
Subjects
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antifungal agents
Antifungal Agents - chemical synthesis
Antifungal Agents - chemistry
Antifungal Agents - pharmacology
Biological and medical sciences
Candida - drug effects
Cryptococcus neoformans - drug effects
Dioxanes - chemistry
Dioxolanes - chemistry
Indenes
Medical sciences
Microbial Sensitivity Tests
Pharmacology. Drug treatments
Structure-Activity Relationship
Candida albicans
Terpenoid
Aldehydoacid
Cryptococcus neoformans
Candida glabrata
Tetracyclic compound
In vitro
Fungi
Antifungal agent
Chemical modification
Synthetic product
Structure activity relation
Carboxylic acid
Anomer
Candida kefyr
Diterpene
Candida tropicalis
Glycoside
Fungi Imperfecti
Thallophyta
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Summary:A number of novel 3′,4′-fused dioxolane and dioxane sordarin derivatives were synthesised for structure–activity relationship studies. Many of these derivatives exhibit high activity against Candida spp. and Cryptococcus neoformans. A number of novel 3′,4′-fused sordarin derivatives were synthesised. Antifungal activity is reported.
ISSN:0960-894X
1464-3405
DOI:10.1016/S0960-894X(01)00730-2