PLGA‐PEG‐PLGA Polymer: From Synthesis to Advanced Pharmaceutical Applications

• Published in: Advances in polymer technology Vol. 2025; no. 1
• Main Authors: Strus, Bartosz, Szterk, Arkadiusz
• Format: Journal Article
• Language: English
• Published: London John Wiley & Sons, Inc 01.01.2025; Wiley
• Subjects: Acids; Biocompatibility; Biodegradation; Block copolymers; Body temperature; Cancer; Chemical synthesis; Chemotherapy; Copolymers; Drug carriers; Drug delivery systems; Drugs; Exenatide; Hydrogels; In vivo methods and tests; Molecular weight; Polyethylene glycol; Polymer industry; Polymerization; Polymers; Ratios; Ring opening polymerization; Sol-gel processes; Technology application; Temperature; Toxicity; Vehicles
• ISSN: 0730-6679; 1098-2329
• DOI: 10.1155/adv/8899828

This paper presents an in‐depth analysis of the PLGA‐PEG‐PLGA polymer, focusing on its synthesis and applications in advanced drug delivery systems (DDSs). PLGA‐PEG‐PLGA, a triblock copolymer, gains attention due to its biodegradability, biocompatibility, and thermosensitive properties, making it suitable for encapsulating both hydrophilic and hydrophobic compounds. The polymer’s ability to undergo sol‐to‐gel at body temperature allows controlled and targeted drug release, significantly enhancing the solubility of poorly soluble drugs, such as paclitaxel and irinotecan. The paper discusses the polymer’s synthesis via ring‐opening polymerization (ROP) and explores its optimization using various methods, including microwave‐assisted techniques and supercritical CO 2 . Additionally, it examines the polymer’s cytotoxicity in in vitro and in vivo studies, emphasizing its low toxicity and ability to deliver chemotherapeutic agents more effectively. The study highlights the polymer’s potential in cancer therapy, biopharmaceutical delivery, and the development of dual‐sensitive drug carriers.