Selective association of S100A6 (calcyclin)-immunoreactive astrocytes with the tangential migration pathway of subventricular zone cells in the rat

• Published in: Brain research Vol. 778; no. 2; pp. 388 - 392
• Main Authors: Yamashita, Norifumi, Kosaka, Katsuko, Ilg, Evelyn C, Schäfer, Beat W, Heizmann, Claus W, Kosaka, Toshio
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 19.12.1997
• Subjects: Animals; Antibodies; Astrocyte; Astrocytes - chemistry; Astrocytes - cytology; Brain; Calcium; Calcium-Binding Proteins - analysis; Calcium-Binding Proteins - immunology; Calcyclin; Cell Communication; Cell Cycle Proteins; Cell Movement; Cerebral Ventricles - cytology; Epidermal Growth Factor - analysis; Epidermal Growth Factor - immunology; Male; Microscopy, Confocal; Neuronal migration pathway; Neurons - cytology; Olfactory Bulb - cytology; Rat; Rats; Rats, Wistar; S100 Calcium Binding Protein A6; S100 Proteins; Brain; Calcyclin; Neuronal migration pathway; Astrocyte; Calcium; Rat
• ISSN: 0006-8993; 1872-6240
• DOI: 10.1016/S0006-8993(97)01025-1

In adult rodents, proliferating cells in the subventricular zone of lateral ventricle tangentially migrate into the olfactory bulb, where they become the interneurons. The present immunocytochemical analysis revealed that S100A6 (calcyclin), a specific calcium-binding protein of the S100 family, is restrictedly distributed in some astrocytes in the tangential migration pathway of the rat. These results suggest that a particular type of astrocytes containing S100A6 is associated with the tangential migration pathway.