Transcatheter arterial chemoembolization combined with PD-1 inhibitors and Lenvatinib for hepatocellular carcinoma with portal vein tumor thrombus

BACKGROUND Hepatocellular carcinoma (HCC) patients complicated with portal vein tumor thrombus (PVTT) exhibit poor prognoses and treatment responses. AIM To investigate efficacies and safety of the combination of PD-1 inhibitor, transcatheter arterial chemoembolization (TACE) and Lenvatinib in HCC s...

Full description

Saved in:
Bibliographic Details
Published inWorld journal of gastroenterology : WJG Vol. 30; no. 8; pp. 843 - 854
Main Authors Wu, Hong-Xiao, Ding, Xiao-Yan, Xu, Ya-Wen, Yu, Ming-Hua, Li, Xiao-Mi, Deng, Na, Chen, Jing-Long
Format Journal Article
LanguageEnglish
Published United States Baishideng Publishing Group Inc 28.02.2024
Subjects
Retrospective Study
Hepatocellular carcinoma
Lenvatinib
PD-1 inhibitor
Transcatheter arterial chemoembolization
Portal vein tumor thrombus
Online AccessGet full text

Cover

More Information
Summary:BACKGROUND Hepatocellular carcinoma (HCC) patients complicated with portal vein tumor thrombus (PVTT) exhibit poor prognoses and treatment responses. AIM To investigate efficacies and safety of the combination of PD-1 inhibitor, transcatheter arterial chemoembolization (TACE) and Lenvatinib in HCC subjects comorbid with PVTT. METHODS From January 2019 to December 2020, HCC patients with PVTT types I-IV were retrospectively enrolled at Beijing Ditan Hospital. They were distributed to either the PTL or TACE/Lenvatinib (TL) group. The median progression-free survival (mPFS) was set as the primary endpoint, while parameters like median overall survival, objective response rate, disease control rate (DCR), and toxicity level served as secondary endpoints. RESULTS Forty-one eligible patients were finally recruited for this study and divided into the PTL (n = 18) and TL (n = 23) groups. For a median follow-up of 21.8 months, the DCRs were 88.9% and 60.9% in the PTL and TL groups (P = 0.046), res-pectively. Moreover, mPFS indicated significant improvement (HR = 0.25; P < 0.001) in PTL-treated patients (5.4 months) compared to TL-treated (2.7 months) patients. There were no treatment-related deaths or differences in adverse events in either group. CONCLUSION A triplet regimen of PTL was safe and well-tolerated as well as exhibited favorable efficacy over the TL regimen for advanced-stage HCC patients with PVTT types I-IV.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Author contributions: Chen JL and Ding XX designed the research; Wu HX, Xu YW, Yu MH, Li XM and Deng N contributed data collection; Chen JL, Ding XX, Wu HX, Xu YW, Yu MH, Li XM and Deng N contributed manuscript review; Wu HX and Ding XY performed the research, wrote the paper, and completed data collection, data analysis and manuscript revision, so we consider these two authors to have equal contributions and can be regarded as a co-first author; all authors have read and agreed to the published version of the manuscript.
Co-first authors: Hong-Xiao Wu and Xiao-Yan Ding.
Corresponding author: Jing-Long Chen, Doctor, Chief Doctor, Cancer Center, Beijing Ditan Hospital, Capital Medical University, No. 8 Jingshun East Street, Chaoyang District, Beijing 100015, China. cjl6412@ccmu.edu.cn
ISSN:1007-9327
2219-2840
2219-2840
DOI:10.3748/wjg.v30.i8.843