Adsorbed pluronics on the skin of human volunteers: effects on bacterial adhesion

An amphiphilic copolymer, Pluronic F127, has been deposited, by adsorption, to the skin of human volunteers and the ability of the coated skin to resist bacterial colonisation has been evaluated. In parallel, the ability of the same copolymer to act as a bacterial release agent has been evaluated. I...

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Published inInternational journal of pharmaceutics Vol. 251; no. 1; pp. 155 - 163
Main Authors Marsh, Lorraine H, Alexander, Cameron, Coke, Mark, Dettmar, Peter W, Havler, Michael, Nevell, Thomas G, Smart, John D, Timmins, Barry, Tsibouklis, John
Format Journal Article
LanguageEnglish
Published Amsterdam Elsevier B.V 30.01.2003
Elsevier
Subjects
Adsorption - drug effects
Bacterial Adhesion - drug effects
Bacterial Adhesion - physiology
Bacterial-release coatings
Biological and medical sciences
General pharmacology
Humans
In vivo evaluation
Medical sciences
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Pluronic F127
Poloxamer - pharmacokinetics
Poloxamer - pharmacology
Skin Absorption - drug effects
Skin Absorption - physiology
Bacterial-release coatings
Pluronic F127
In vivo evaluation
Human
Evaluation
Adhesion
Amphiphilic compound
In vivo
Bacteria
Skin
Copolymer
Coating
Release
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Summary:An amphiphilic copolymer, Pluronic F127, has been deposited, by adsorption, to the skin of human volunteers and the ability of the coated skin to resist bacterial colonisation has been evaluated. In parallel, the ability of the same copolymer to act as a bacterial release agent has been evaluated. In both cases, F127 proved to be of little added value in formulations designed to suppress the bacterial colonisation of human skin.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0378-5173
1873-3476
DOI:10.1016/S0378-5173(02)00592-6