Pharmacological evaluation of bee venom and melittin

The objective of this study was to identify the pharmacological effects of bee venom and its major component, melittin, on the nervous system of mice. For the pharmacological analysis, mice were treated once with saline, 0.1 or 1.2mg/kg of bee venom and 0.1mg/kg of melittin, subcutaneously, 30min be...

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Published inRevista brasileira de farmacognosia Vol. 24; no. 1; pp. 67 - 72
Main Authors Dantas, Camila G., Nunes, Tássia L.G.M., Nunes, Tâmara L.G.M., da Paixão, Ailma O., Reis, Francisco P., Júnior, Waldecy de L., Cardoso, Juliana C., Gomes, Margarete Z., Gramacho, Kátia P.
Format Journal Article
LanguageEnglish
Portuguese
Published Elsevier Editora Ltda 01.01.2014
Sociedade Brasileira de Farmacognosia
Subjects
Bee venom
Dopamine
Haloperidol
PHARMACOLOGY & PHARMACY
Bee venom
Dopamine
Haloperidol
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Summary:The objective of this study was to identify the pharmacological effects of bee venom and its major component, melittin, on the nervous system of mice. For the pharmacological analysis, mice were treated once with saline, 0.1 or 1.2mg/kg of bee venom and 0.1mg/kg of melittin, subcutaneously, 30min before being submitted to behavioral tests: locomotor activity and grooming (open-field), catalepsy, anxiety (elevated plus-maze), depression (forced swimming test) and apomorphine-induced stereotypy. Haloperidol, imipramine and diazepam were administered alone (positive control) or as a pre-treatment (haloperidol). The bee venom reduced motor activity and promoted cataleptic effect, in a similar manner to haloperidol. These effects were decreased by the pretreatment with haloperidol. Both melittin and bee venom decreased the apomorphine-induced stereotypies. The data indicated the antipsychotic activity of bee venom and melittin in a murine model.
ISSN:0102-695X
1981-528X
1981-528X
DOI:10.1590/0102-695X20142413365