Efficacy of Rhino-Protect ointment after endoscopic sinus surgery: a prospective, randomized, multicenter study

• Published in: European archives of oto-rhino-laryngology Vol. 278; no. 1; pp. 109 - 115
• Main Authors: Cho, Kyu-Sup, Kim, Soo Whan, Kim, Jin Kook, Kim, Chang-Hoon
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.01.2021
• Subjects: Adult; Aged; Chronic Disease; Endoscopy - adverse effects; Female; Head and Neck Surgery; Humans; Male; Medicine; Medicine & Public Health; Middle Aged; Neurosurgery; Ointments - therapeutic use; Otorhinolaryngologic Surgical Procedures - adverse effects; Otorhinolaryngology; Paranasal Sinuses - surgery; Postoperative Complications - prevention & control; Prospective Studies; Rhinitis - drug therapy; Rhinitis - surgery; Rhinology; Sinusitis - surgery; Treatment Outcome; PRS; Wound healing; Endoscopic sinus surgery; Postoperative care; Nose; Dr. Theiss Rhino-Protect; Dr. Theiss Rhino-Protect® PRS
• ISSN: 0937-4477; 1434-4726; 1434-4726
• DOI: 10.1007/s00405-020-06265-4

Objective Blocking airflow into the sinonasal cavity after surgery may help to keep the cavity moist and thus decrease postoperative crusting. Here we investigated the efficacy of Rhino-Protect ointment following endoscopic sinus surgery (ESS). Subjects and methods A total of 93 patients with chronic rhinosinusitis who underwent identical ESS were enrolled. After surgery, all patients were instructed to perform nasal saline irrigation and deliver a nasal spray to each nostril, then to apply Rhino-Protect ointment to one nostril only; the other nostril served as a control. Subjective symptoms, postoperative Lund–Kennedy (LK) endoscopic scores, and adverse reactions 14 and 28 days after treatment were evaluated. Results The Rhino-Protect ointment significantly reduced pain ( p  = 0.015 at 28 days), dryness ( p  = 0.009 at 14 days and p  = 0.045 at 28 days), and crusting ( p  = 0.047 at 14 days), and was associated with significantly lower LK scores 14 and 28 days after treatment ( p  = 0.037 and p  = 0.007, respectively). Statistically significant differences were noted in the LK edema subscore at 14 days ( p  = 0.043) and in LK crusting subscores at 14 and 28 days ( p  = 0.005 and p  = 0.006, respectively). No patient reported any serious adverse event associated with Rhino-Protect use. Conclusion Applying Rhino-Protect after ESS significantly reduced the formation of edema and crusts, leading to improving the patients’ discomfort for pain, dryness, and crust.