Calprotectin-g the Lung during Type 2 Allergic Airway Inflammation

Manni and Alcorn discuss the study by Palmer and colleagues which examine the role of S100A9-calprotectin in allergic airway inflammation in mice. Although calprotectin is implicated in the pathogenesis of inflammatory diseases by functioning as a ligand for Toll-like receptor 4 and receptor for adv...

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Bibliographic Details
Published inAmerican journal of respiratory cell and molecular biology Vol. 61; no. 4; pp. 405 - 407
Main Authors Manni, Michelle L, Alcorn, John F
Format Journal Article
LanguageEnglish
Published United States American Thoracic Society 01.10.2019
Subjects
Adaptive immunity
Advanced glycosylation end products
Airway management
Allergies
Glycosylation
Humans
Immune response
Immunity, Innate
Inflammation
Inflammatory diseases
Leukocyte L1 Antigen Complex
Lung
Pathogenesis
Respiratory tract
Respiratory tract diseases
Studies
Th2 Cells
TLR4 protein
Toll-like receptors
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Summary:Manni and Alcorn discuss the study by Palmer and colleagues which examine the role of S100A9-calprotectin in allergic airway inflammation in mice. Although calprotectin is implicated in the pathogenesis of inflammatory diseases by functioning as a ligand for Toll-like receptor 4 and receptor for advanced glycation end products (TLR4 and RAGE), this study elucidates an alternative and antiinflammatory mechanism by which S100A9 influences innate and adaptive immune responses.
ISSN:1044-1549
1535-4989
DOI:10.1165/rcmb.2019-0125ED