Relative Potency of Several Forms of α-Tocopherols in the Chick Liver Storage Bioassay

• Published in: The Journal of nutrition Vol. 104; no. 1; pp. 79 - 83
• Main Authors: Matterson, L.D., Pudelkiewicz, W.J.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.01.1974
• Subjects: Acetates - analysis; Acetates - metabolism; Animal Nutritional Physiological Phenomena; animal science; Animals; Biological Assay; Chickens; Evaluation Studies as Topic; liver; Liver - metabolism; livestock; Mathematics; Methods; Stereoisomerism; Structure-Activity Relationship; Time Factors; vitamin E; Vitamin E - analysis; Vitamin E - metabolism; Vitamin E - therapeutic use; Vitamin E Deficiency - drug therapy; zoology; α-tocopherol; liver; vitamin E; α-tocopherol
• ISSN: 0022-3166; 1541-6100
• DOI: 10.1093/jn/104.1.79

The relative potencies of different tocopherol preparations using a chick liver storage bioassay have been studied over a period of 6 years. Data pooled from 22 experiments and using 16 different tocopherol preparations show that, with this assay, the naturally occurring form (α-tocopherol) is 1.21 times more effective than the synthetic (all-rac.-α-tocopherol) form. Studies also showed that 2l-α-tocopherol was deposited in the liver at levels considerably higher than would be expected from results using other criteria of measurement.