Plasma concentrations and analgesic effect of EMLA (Lidocaine/Prilocaine) cream for the cleansing of leg ulcers
Plasma concentrations of lidocaine and prilocaine were assessed in 8 patients after the application of 8-10 g EMLA 2% cream for 60 min to leg ulcers measuring 31-80 cm2. Maximum individual plasma concentrations were 205 ng/ml for lidocaine and 79 ng/ml for prilocaine, which is twenty times lower tha...
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Published in | Acta dermato-venereologica Vol. 70; no. 3; pp. 227 - 230 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
Uppsala
Acta dermato-venereologica
01.01.1990
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Subjects | |
Online Access | Get full text |
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Summary: | Plasma concentrations of lidocaine and prilocaine were assessed in 8 patients after the application of 8-10 g EMLA 2% cream for 60 min to leg ulcers measuring 31-80 cm2. Maximum individual plasma concentrations were 205 ng/ml for lidocaine and 79 ng/ml for prilocaine, which is twenty times lower than those associated with toxicity. The analgesic effect of EMLA 2% and 5% cream for the surgical cleansing of leg ulcers was compared in a double-blind, four-period, cross-over study in 10 patients. The ulcer was covered with a thick layer of cream for 30 min before four consecutive debridements 1-4 days apart. While the 2% and 5% creams had similar analgesic effects post-cleansing pain tended to be more frequent with the 2% cream. |
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ISSN: | 0001-5555 1651-2057 |
DOI: | 10.2340/0001555570227230 |