Update on the use of 45S5 bioactive glass in the treatment of bone defects in regenerative medicine

• Published in: World journal of orthopedics Vol. 15; no. 3; pp. 204 - 214
• Main Authors: Nogueira, Dayane Maria Braz, Rosso, Marcelie Priscila de Oliveira, Buchaim, Daniela Vieira, Zangrando, Mariana Schutzer Ragghianti, Buchaim, Rogério Leone
• Format: Journal Article
• Language: English
• Published: United States Baishideng Publishing Group Inc 18.03.2024
• Subjects: Bone regeneration; Biocompatible materials; Bioglass
• ISSN: 2218-5836; 2218-5836
• DOI: 10.5312/wjo.v15.i3.204

Bone regeneration is a critical area in regenerative medicine, particularly in orthopedics, demanding effective biomedical materials for treating bone defects. 45S5 bioactive glass (45S5 BG) is a promising material because of its osteoconductive and bioactive properties. As research in this field continues to advance, keeping up-to-date on the latest and most successful applications of this material is imperative. To achieve this, we conducted a comprehensive search on PubMed/MEDLINE, focusing on English articles published in the last decade. Our search used the keywords "bioglass 45S5 AND bone defect" in combination. We found 27 articles, and after applying the inclusion criteria, we selected 15 studies for detailed examination. Most of these studies compared 45S5 BG with other cement or scaffold materials. These comparisons demonstrate that the addition of various composites enhances cellular biocompatibility, as evidenced by the cells and their osteogenic potential. Moreover, the use of 45S5 BG is enhanced by its antimicrobial properties, opening avenues for additional investigations and applications of this biomaterial.