Human marginal-zone B cells

Marginal-zone B cells are likely to be the first B cells in lymphoid tissue to encounter antigen. Here, Jo Spencer and colleagues review their distribution, properties and malignancies, and suggest that they are designated `marginal-zone B cells' because of their phenotype and location, and tha...

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Published inImmunology today (Amsterdam. Regular ed.) Vol. 19; no. 9; pp. 421 - 426
Main Authors Spencer, Jo, Perry, Marta E, Dunn-Walters, Deborah K
Format Journal Article
LanguageEnglish
Published England Elsevier B.V 01.09.1998
Subjects
Animals
B cells
B-Lymphocytes - pathology
B-Lymphocytes - physiology
human
Humans
Immunoenzyme Techniques
Immunoglobulin Variable Region - genetics
lymph node
Lymphoma, B-Cell, Marginal Zone - pathology
marginal zone
Peyer's patches
spleen
Spleen - cytology
Spleen - pathology
Peyer's patches
B cells
spleen
human
lymph node
marginal zone
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Summary:Marginal-zone B cells are likely to be the first B cells in lymphoid tissue to encounter antigen. Here, Jo Spencer and colleagues review their distribution, properties and malignancies, and suggest that they are designated `marginal-zone B cells' because of their phenotype and location, and that this does not reflect a specific function, since the population appears to be functionally heterogeneous.
Bibliography:ObjectType-Article-2
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ObjectType-Review-3
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ISSN:0167-5699
DOI:10.1016/S0167-5699(98)01308-5