Mechanisms underlying T-cell tolerance
To understand how the immune system manages to disarm potentially harmful T cells with reactivity against self-antigens, many immunologists have turned to model systems in which transgenic expression of TCRs, foreign antigens, or both, allows visualization of otherwise undetectable mechanisms. Recen...
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Published in | Current opinion in immunology Vol. 8; no. 2; pp. 233 - 244 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
England
Elsevier Ltd
01.04.1996
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Subjects | |
Online Access | Get full text |
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Summary: | To understand how the immune system manages to disarm potentially harmful T cells with reactivity against self-antigens, many immunologists have turned to model systems in which transgenic expression of TCRs, foreign antigens, or both, allows visualization of otherwise undetectable mechanisms. Recent data have offered several new insights into the variables that dictate the mechanism for tolerance employed by peripheral T cells. Some of these mechanisms can also dampen ongoing immune responses against foreign antigens and provide a strikingly powerful supplement to the primary mechanism of tolerance, thymic clonal deletion. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 ObjectType-Review-3 content type line 23 ObjectType-Feature-3 ObjectType-Review-1 |
ISSN: | 0952-7915 1879-0372 |
DOI: | 10.1016/S0952-7915(96)80062-8 |