Association between Hyperuricemia and Ischemic Stroke: A Case-Control Study

• Published in: Journal of the College of Physicians and Surgeons--Pakistan Vol. 30; no. 8; pp. 853 - 856
• Main Authors: Fatima, Tooba, Iftikhar, Sadaf, Qureshi, Irshad Hussain
• Format: Journal Article
• Language: English
• Published: College of Physicians and Surgeons Pakistan 01.08.2020
• Subjects: Hyperuricemia; Risk factors; Stroke (Disease); Pakistan
• ISSN: 1022-386X; 1681-7168
• DOI: 10.29271/jcpsp.2020.08.853

Objective: To And the association between hyperuricemia and ischemic stroke. Study Design: Case-control study. Place and Duration of Study: Departments of Medicine and Neurology, Mayo Hospital, Lahore, from October 2015 to September 2016. Methodology: A total of 100 patients were recruited in the study. Fifty cases were of acute ischemic stroke and fifty were age- and gender-matched healthy controls. Serum uric acid level was estimated by photometry method at the time of admission. Hyperuricemia was defined as the serum uric acid level of more than 6 mg/dl. Results: Mean serum uric acid levels in cases and controls were 5.996 [+ or -] 1.99 mg/dl and 5.042 [+ or -] 0.91 mg/dl, respectively. Hyperuricemia was present in 23 (46%) patients with ischemic stroke and in 10 (20%) controls. Among ischemic stroke patients, the frequency of hyperuricemia was significantly higher than in controls (p-value =0.006, Odds Ratio (OR) =3.41.) Conclusion: Serum uric acid was found significantly elevated in ischemic stroke patients versus controls with 3.41 times more risk of having hyperuricemia in ischemic stroke patients. Key Words: Hyperuricemia, Ischemic stroke, Serum uric acid (SUA).