Electrochemical oxidation of cisatracurium on carbon paste electrode and its analytical applications

The electrochemical oxidation of cisatracurium was investigated by cyclic voltammetry and differential pulse voltammetry at a carbon paste electrode and the experimental parameters have been optimized in order to obtain the optimum analytical signal. A differential pulse voltammetric method with car...

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Published inTalanta (Oxford) Vol. 53; no. 6; pp. 1179 - 1185
Main Authors Torres, R.Fernández, Mochón, M.Callejón, Sánchez, J.C.Jiménez, Bello López, M.A, Pérez, A.Guiraúm
Format Journal Article
LanguageEnglish
Published Amsterdam Elsevier B.V 16.03.2001
Oxford Elsevier
Subjects
Analysis
Biological and medical sciences
Carbon paste electrode
Cisatracurium
Differential pulse voltammetry
General pharmacology
Medical sciences
Pharmacology. Drug treatments
Serum
Urine
Urine
Serum
Cisatracurium
Carbon paste electrode
Differential pulse voltammetry
Human
Biological fluid
Non depolarisant myorelaxant
Cisatracurium besilate
Differential impulse voltamperometry
Carbon electrode
Blood
Quantitative analysis
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Summary:The electrochemical oxidation of cisatracurium was investigated by cyclic voltammetry and differential pulse voltammetry at a carbon paste electrode and the experimental parameters have been optimized in order to obtain the optimum analytical signal. A differential pulse voltammetric method with carbon paste electrode is described for the determination of cisatracurium with detection limit of 0.38 μg/ml and quantitation limit of 1.26 μg/ml. The proposed method was applied to determine the content of cisatracurium in human urine and human serum, obtaining accurate and precise results.
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ISSN:0039-9140
1873-3573
DOI:10.1016/S0039-9140(00)00604-4