Assessment of the antibacterial activity of phenylethanoid glycosides from Phlomis lanceolata against multiple-drug-resistant strains of Staphylococcus aureus
Three phenylethanoid glycosides, forsythoside B ( 1 ), phlinoside C ( 2 ) and verbascoside ( 3 ), were isolated from the methanol extract of the leaves of Phlomis lanceolata , an Iranian medicinal plant, by reversed-phase preparative high-performance liquid chromatography (HPLC), and the structures...
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Published in | Journal of natural medicines Vol. 62; no. 1; pp. 91 - 95 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Tokyo
Springer-Verlag
01.01.2008
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Subjects | |
Online Access | Get full text |
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Summary: | Three phenylethanoid glycosides, forsythoside B (
1
), phlinoside C (
2
) and verbascoside (
3
), were isolated from the methanol extract of the leaves of
Phlomis lanceolata
, an Iranian medicinal plant, by reversed-phase preparative high-performance liquid chromatography (HPLC), and the structures of these compounds were elucidated conclusively by ultraviolet (UV), mass spectrometry (MS) and a series of 1D and 2D nuclear magnetic resonance (NMR) analyses. The antibacterial properties of
1
–
3
against five multi-drug-resistant (MDR) strains of
Staphylococcus aureus
have been assessed by the rapid and robust microtitre-plate-based serial dilution method. While compounds
1
and
3
showed considerable activities against all five strains, compound
2
was inactive at the test concentrations. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1340-3443 1861-0293 |
DOI: | 10.1007/s11418-007-0194-z |