Chiral transition metal complexes: Synthetic approach and biological applications

• Published in: Inorganica Chimica Acta Vol. 458; pp. 8 - 27
• Main Authors: Sharma, Surbhi, Chauhan, Mala, Jamsheera, A., Tabassum, Sartaj, Arjmand, Farukh
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 24.03.2017; Elsevier Science Ltd
• Subjects: Agrochemicals; Biomimetic enzyme models; Biomimetics; Catalysis; Chirality; Coordination compounds; Diagnostic software; Diagnostic systems; Flavors; Food additives; Fragrances; Fungicides; Interdisciplinary studies; Metals; Molecular chains; Molecular recognition; Nucleic acid probes; Pharmaceuticals; Reagents; Synthetic biology; Transition metal complexes; Biomimetic enzyme models; Molecular recognition; Nucleic acid probes; Transition metal complexes; Chirality; Pharmaceuticals
• ISSN: 0020-1693; 1873-3255
• DOI: 10.1016/j.ica.2016.12.011

[Display omitted] •Survey of classification and synthetic strategies to achieve chiral assemblies with transition metal complexes.•Vast majority of the complexes containing chiral ligands and their biological applications has been covered.•Chiral molecules have attracted eminent attention due to their implication in pharmaceutical and industrial catalysts.•The structural difference between enantiomers can be serious with respect to the actions of synthetic drugs. Chiral metal complexes render new breakthroughs in chemical sciences by providing stereoselective, robust and enantiomerically pure compounds and their applications as pharmaceuticals, diagnostic agents, in supramolecular assemblies, enzyme catalysis, biomimetic model systems and as nucleic acid probes. Recent progress in interdisciplinary research has motivated researchers to look for innovative measures to improve the quality of life and spurred various efforts directed towards the creation of molecularly engineered novel synthetic agents. The use of food additives, flavors, agrochemicals, pharmaceuticals and new medical diagnostic agents is indispensible in modern era, therefore to foster this concept, synthetic methodologies have to be monitored carefully. The growth of this core technology has given rise to enormous economic potential in the manufacture of pharmaceuticals, fungicides, flavors, and fragrances. As this subject is an essential component of molecular science, this review deals with the most representative contributions in the field of chiral transition metal complexes, their synthetic methodology and biological applications.