Health Care Workers’ Reasons for Choosing Between Two Different COVID-19 Prophylaxis Trials in an Acute Pandemic Context: Single-Center Questionnaire Study

• Published in: Journal of medical Internet research Vol. 23; no. 2; p. e23441
• Main Authors: Borobia, Alberto M, García-García, Irene, Díaz-García, Lucía, Rodríguez-Mariblanca, Amelia, Martínez de Soto, Lucía, Monserrat Villatoro, Jaime, Seco Meseguer, Enrique, González, Juan J, Frías Iniesta, Jesús, Ramírez García, Elena, Arribas, Jose Ramón, Carcas-Sansuán, Antonio J
• Format: Journal Article
• Language: English
• Published: Canada Gunther Eysenbach MD MPH, Associate Professor 25.02.2021; JMIR Publications
• Subjects: Adult; Antiretroviral drugs; Attitude of Health Personnel; Clinical research; Clinical trials; Combination therapy; Coronaviruses; COVID-19; COVID-19 - drug therapy; COVID-19 - epidemiology; COVID-19 - psychology; Critical incidents; Disease prevention; Disease transmission; Efficacy; Female; Health care; Health Personnel - psychology; Humans; Infections; Internet; Knowledge; Male; Medical personnel; Medical screening; Melatonin; Middle Aged; Multimedia; News; Nurses; Original Paper; Pandemics; Physicians; Polls & surveys; Questionnaires; Randomized Controlled Trials as Topic - methods; Randomized Controlled Trials as Topic - psychology; SARS-CoV-2 - isolation & purification; Severe acute respiratory syndrome; Severe acute respiratory syndrome coronavirus 2; Surveys and Questionnaires; Volunteers; Workers; United States > US; COVID-19; SARS-CoV-2; health care worker; professional practice; pre-exposure; workplace safety; motivation; clinical trials; personnel; volunteers, web-based survey; prophylaxis
• ISSN: 1438-8871; 1439-4456; 1438-8871
• DOI: 10.2196/23441

In April 2020, two independent clinical trials to assess SARS-CoV-2 prophylaxis strategies among health care workers were initiated at our hospital: MeCOVID (melatonin vs placebo) and EPICOS (tenofovir disoproxil/emtricitabine vs hydroxychloroquine vs combination therapy vs placebo). This study aimed to evaluate the reasons why health care workers chose to participate in the MeCOVID and EPICOS trials, as well as why they chose one over the other. Both trials were offered to health care workers through an internal news bulletin. After an initial screening visit, all subjects were asked to respond to a web-based survey. In the first month, 206 health care workers were screened and 160 were randomized. The survey participation was high at 73.3%. Health care workers cited "to contribute to scientific knowledge" (n=80, 53.0%), followed by "to avoid SARS-CoV-2 infection" (n=33, 21.9%) and "the interest to be tested for SARS-CoV-2" (n=28, 18.5%), as their primary reasons to participate in the trials. We observed significant differences in the expected personal benefits across physicians and nurses (P=.01). The vast majority of volunteers (n=202, 98.0%) selected the MeCOVID trial, their primary reason being their concern regarding adverse reactions to treatments in the EPICOS trial (n=102, 69.4%). Health care workers' reasons to participate in prophylaxis trials in an acute pandemic context appear to be driven largely by their desire to contribute to science and to gain health benefits. Safety outweighed efficacy when choosing between the two clinical trials.