Generation of human induced iPSC KUMi003-A from acute promyelocytic leukemia (APL) M3

Acute promyelocytic leukemia (APL) M3 is an acute myeloid leukemia (AML) subtype and is characterized by the chromosomal translocation t(15;17)(p22;q11), which results in the fusion of the promyelocytic gene (PML) at 15q22 with the retinoic acid α-receptor gene (RARA) at 17q21. We generated an induc...

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Published inStem cell research Vol. 63; p. 102861
Main Authors Kim, Ji-Hea, Kang, Ka-Won, Lee, Byung-Hyun, Park, Young, Kim, Byung-Soo
Format Journal Article
LanguageEnglish
Published Elsevier B.V 01.08.2022
Elsevier
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Summary:Acute promyelocytic leukemia (APL) M3 is an acute myeloid leukemia (AML) subtype and is characterized by the chromosomal translocation t(15;17)(p22;q11), which results in the fusion of the promyelocytic gene (PML) at 15q22 with the retinoic acid α-receptor gene (RARA) at 17q21. We generated an induced pluripotent stem cell line “KUMi003-A” from an APL M3 patient that is pluripotent and can differentiate into the three germ layers. This iPSC line will be useful as a disease model to investigate disease mechanisms specific to APL M3.
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ISSN:1873-5061
1876-7753
DOI:10.1016/j.scr.2022.102861