Anti-annexin V antibodies: are they prothrombotic?

• Published in: Autoimmunity reviews Vol. 4; no. 1; pp. 55 - 60
• Main Authors: Esposito, Gaëtan, Tamby, Mathieu C., Chanseaud, Youri, Servettaz, Amélie, Guillevin, Loïc, Mouthon, Luc
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 2005
• Subjects: Abortion, Habitual - immunology; Annexin A5 - immunology; Anti-annexin V antibodies; Anti-phospholipid syndrome; Antibodies - immunology; Apoptosis - immunology; Humans; Lupus Erythematosus, Systemic - immunology; Recurrent spontaneous abortion; Scleroderma, Systemic - immunology; Systemic lupus erythematosus; Systemic sclerosis; Thrombosis; Thrombosis - immunology; Ab; SSc; lSSc; SRC; APLS; kDA; ACL; Recurrent spontaneous abortion; SLE; Anti-phospholipid syndrome; Thrombosis; dSSc; Systemic lupus erythematosus; PAH; Systemic sclerosis; Anti-annexin V antibodies; aPL; ELISA
• ISSN: 1568-9972; 1568-9972
• DOI: 10.1016/j.autrev.2004.07.006

Annexin V inhibits prothrombin activation and is able to prevent thrombus formation under normal venous and arterial blood flow conditions. Antibodies to annexin V have been identified in association with several pathological conditions, including systemic lupus erythematosus (SLE) with or without anti-phospholipid syndrome, recurrent spontaneous abortions and systemic sclerosis (SSc). These antibodies are suspected to exert a detrimental role and interfere with annexin V function. Thus, they have been associated with the occurrence of foetal loss and venous and/or arterial thrombosis in SLE patients, as well as digital ischemia in SSc patients. However, their true pathogenic role remains to be proven.