Inhibition of activated murine T-lymphocytes by synthetic glycoglycerolipid analogues

• Published in: Farmaco (Società chimica italiana : 1989) Vol. 57; no. 4; pp. 337 - 339
• Main Authors: Colombo, Diego, Ronchetti, Fiamma, Toma, Lucio, Pisano, Barbara, Ianaro, Angela
• Format: Journal Article
• Language: English
• Published: Lausanne Elsevier SAS 01.04.2002; Elsevier Science
• Subjects: Animals; Biological and medical sciences; Cell Division - drug effects; Cells, Cultured; Concanavalin A; Glycoglycerolipids; Glycolipids - pharmacology; Immunomodulators; Immunosuppressive agents; Immunosuppressive Agents - pharmacology; Lymphocyte Activation; Male; Medical sciences; Mice; Pharmacology. Drug treatments; Structure-Activity Relationship; T cells; T-Lymphocytes - drug effects; T cells; Concanavalin A; Immunosuppressive agents; Glycoglycerolipids; Immunomodulator; Synthetic product; T-Lymphocyte; Lipids; In vitro; Monoacylglycerol; Biological activity; Glycolipid
• ISSN: 0014-827X; 1879-0569
• DOI: 10.1016/S0014-827X(02)01203-X

Glycoglycerolipid analogues, characterized by a glycerol aglicone β-linked in position 2 to a glucose or galactose residue, and by a lipophilic C 6 acyl chain on the glycerol unit, significantly inhibit proliferation of activated T cells. The inhibitory activity displayed by such synthetic compounds is comparable to the immunosuppressive properties shown by the natural glycolipids simplexides, to which they are structurally related. Vice versa, when the acyl chain is located on the sugar unit, no immunomodulating activity is observed, suggesting a strict relationship between the activity and the location of the acyl chain.