Changes of immunoreactive neuropeptide Y, somatostatin and corticotropin-releasing factor (CRF) in the brain of a novel epileptic mutant rat, Ihara's genetically epileptic rat (IGER)

Ihara's genetically epileptic rat (IGER) is a rat mutant with genetically scheduled spontaneous convulsions mimicking human limbic seizures. In the present study, the possible changes of three neuropeptides, neuropeptide Y (NPY), somatostatin (SRIF) and corticotropin-releasing factor (CRF), in...

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Published inBrain research Vol. 776; no. 1; pp. 255 - 260
Main Authors Takahashi, Yoshinari, Sadamatsu, Miyuki, Kanai, Hirohiko, Akira Masui, Amano, Shigeru, Ihara, Nobuo, Kato, Nobumasa
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 21.11.1997
Subjects
Animals
Antibody Specificity
Brain Chemistry
Corticotropin-releasing factor
Corticotropin-Releasing Hormone - analysis
Corticotropin-Releasing Hormone - metabolism
Disease Models, Animal
Epilepsy
Epilepsy - genetics
Epilepsy - metabolism
Female
Ihara's genetically epileptic rat
Male
Neuropeptide Y
Neuropeptide Y - analysis
Neuropeptide Y - metabolism
Rats
Rats, Mutant Strains
Rats, Wistar
Somatostatin
Somatostatin - analysis
Somatostatin - metabolism
Neuropeptide Y
Corticotropin-releasing factor
Somatostatin
Ihara's genetically epileptic rat
Epilepsy
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Summary:Ihara's genetically epileptic rat (IGER) is a rat mutant with genetically scheduled spontaneous convulsions mimicking human limbic seizures. In the present study, the possible changes of three neuropeptides, neuropeptide Y (NPY), somatostatin (SRIF) and corticotropin-releasing factor (CRF), in the brains of IGER were investigated. Increased contents of immunoreactive (IR) NPY were found only in the hippocampus of 2-month IGERs before developing convulsive seizures, while similar increases of IR-NPY were discovered in the striatum and pyriform and entorhinal cortex as well as hippocampus in 8-month IGERs with repetitive seizures. There were no significant differences in the brain contents of IR-SRIF and IR-CRF between IGERs and the controls at both ages. These findings indicate an enhanced rate of NPY synthesis in this experimental model of epilepsy which may play a critical role in the development of epileptogenesis.
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ISSN:0006-8993
1872-6240
DOI:10.1016/S0006-8993(97)01119-0