The efficacy of lafutidine in improving preoperative gastric fluid property: A comparison with ranitidine and rabeprazole

• Published in: Anesthesia and analgesia Vol. 95; no. 1; pp. 144 - 147
• Main Authors: UESUGI, Takanobu, MIKAWA, Katsuya, NISHINA, Kahoru, MORIKAWA, Osamu, TAKAO, Yumiko, OBARA, Hidefumi
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott 01.07.2002
• Subjects: 2-Pyridinylmethylsulfinylbenzimidazoles; Acetamides - therapeutic use; Adult; Aged; Anesthesia; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Anti-Ulcer Agents - therapeutic use; Benzimidazoles - therapeutic use; Biological and medical sciences; Digestive system; Enzyme Inhibitors - therapeutic use; Female; Gastric Acid - physiology; Gastric Acidity Determination; General anesthesia. Technics. Complications. Neuromuscular blocking. Premedication. Surgical preparation. Sedation; Histamine H2 Antagonists - therapeutic use; Humans; Intraoperative Complications - epidemiology; Intubation, Gastrointestinal; Male; Medical sciences; Middle Aged; Omeprazole - analogs & derivatives; Pharmacology. Drug treatments; Piperidines - therapeutic use; Preoperative Care; Proton Pump Inhibitors; Pyridines - therapeutic use; Rabeprazole; Ranitidine - therapeutic use; Risk Assessment; Stomach - anatomy & histology; Stomach - drug effects; Lafutidine; H; K; Rabeprazole; Proton pump inhibitor; Prevention; Antisecretory agent; Surgery; pH; Complication; Antagonist; Human; Lung disease; Respiratory disease; Enzyme; Enzyme inhibitor; General anesthesia; Trauma; Chemotherapy; Benzimidazole derivatives; Aspiration pneumonia; Volume; Ranitidine; Hydrolases; exchanging ATPase; Comparative study; Gastric juice; H2 Histamine receptor; Premedication
• ISSN: 0003-2999; 1526-7598
• DOI: 10.1097/00000539-200207000-00025

Acid aspiration syndrome remains a potentially critical perioperative complication. We compared lafutidine, ranitidine, and rabeprazole for reduction of preoperative gastric fluid acidity and volume in elective surgery and found that these variables were minimized with a single morning dose of lafutidine 20 mg compared with ranitidine or rabeprazole. Preoperative oral lafutidine may be an alternative to ranitidine as a prophylaxis against aspiration pneumonia.