Tetanus vaccination with IL-2 during highly active antiretroviral therapy induces sustained and pronounced specific CD4 T-cell responses

HIV-1 infection results in profound dysfunction of the CD4 T-cell population. Although highly active antiretroviral therapy allows the reconstitution of CD4 T-cell numbers, functional abnormalities remain, including inadequate responses to vaccination. IL-2 increases CD4 T-cell numbers and function....

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Bibliographic Details
Published inAIDS (London) Vol. 18; no. 16; pp. 2199 - 2202
Main Authors HARDYA, Gareth A. D, IMAMI, Nesrina, SULLIVAN, Ann K, NELSON, Mark R, GAZZARD, Brian, GOTCH, Frances M
Format Journal Article
LanguageEnglish
Published Hagerstown, MD Lippincott Williams & Wilkins 05.11.2004
Subjects
AIDS/HIV
Anti-HIV Agents - therapeutic use
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiretroviral Therapy, Highly Active
Antiviral agents
Bacterial diseases
Bacterial diseases of the nervous system. Bacterial myositis
Biological and medical sciences
CD4 Lymphocyte Count
CD4-Positive T-Lymphocytes - immunology
Combined Modality Therapy
HIV Infections - drug therapy
HIV Infections - immunology
HIV-1
Human bacterial diseases
Human viral diseases
Humans
Infectious diseases
Interleukin-2 - administration & dosage
Medical sciences
Pharmacology. Drug treatments
Tetanus Toxoid - administration & dosage
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
Cell function
HIV-1 virus
Vaccination
Prevention
Interleukin 2
Immunological investigation
Immunotherapy
T-Lymphocyte
Antiviral
Human
Immunopathology
Retroviridae
AIDS
Immune deficiency
Lentivirus
Infection
Virus
Immunoprophylaxis
Chemotherapy
Treatment
Cell population
Dysfunction
Viral disease
Bacteriosis
Human immunodeficiency virus
Timing
Tetanus
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Summary:HIV-1 infection results in profound dysfunction of the CD4 T-cell population. Although highly active antiretroviral therapy allows the reconstitution of CD4 T-cell numbers, functional abnormalities remain, including inadequate responses to vaccination. IL-2 increases CD4 T-cell numbers and function. We report the effects of IL-2 given with tetanus vaccination in two patients in a larger immunotherapy study. In one case IL-2 induced sustained responses, which may have been caused by the timing of IL-2 with vaccination.
Bibliography:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
ObjectType-Feature-4
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ObjectType-Report-1
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ISSN:0269-9370
1473-5571
DOI:10.1097/00002030-200411050-00014