Dendritic localization of mRNAs

The dendritic localization of mRNAs has been proposed to underlie the structural and functional polarity of neurons, as well as certain aspects of synaptic plasticity. Even though there is no conclusive evidence that such a localization is a physiological requirement, studies of mRNA localization in...

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Published inCurrent opinion in neurobiology Vol. 8; no. 5; pp. 600 - 606
Main Authors Kuhl, Dietmar, Skehel, Paul
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.10.1998
Subjects
Animals
Cell Polarity - physiology
Dendrites - chemistry
Dendrites - physiology
Nerve Tissue Proteins - genetics
Neuronal Plasticity - physiology
Neurons - chemistry
Neurons - cytology
Neurons - ultrastructure
RNA, Messenger - analysis
MAP microtubule-associated protein
CAMKII Ca 2+/calmodulin-dependent kinase II
LTP long-term potentiation
UTR untranslated region
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Summary:The dendritic localization of mRNAs has been proposed to underlie the structural and functional polarity of neurons, as well as certain aspects of synaptic plasticity. Even though there is no conclusive evidence that such a localization is a physiological requirement, studies of mRNA localization in relation to function in other cell types and recent experiments on synaptic plasticity suggest that this proposal may be correct.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ISSN:0959-4388
1873-6882
DOI:10.1016/S0959-4388(98)80087-1