Muscular work and the release of prostaglandin-like substances

Experimental evidence for the release of prostaglandin-like substances, mainly of the E type, into the venous outflow from working skeletal muscles in the dog is described. Muscular exercise of the hind-leg produced by sciatic nerve stimulation evoked the release of prostaglandin-like substances det...

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Published inCardiovascular research Vol. 10; no. 4; pp. 413 - 420
Main Authors HERBACZYNSKA-CEDRO, KRYSTYNA, STASZEWSKA-BARCZAK, JANINA, JANCZEWSKA, HENRYKA
Format Journal Article
LanguageEnglish
Published England Oxford University Press 01.07.1976
Subjects
Animals
Carbon Dioxide - blood
Colon - blood supply
Dogs
Electric Stimulation
Gallamine Triethiodide - pharmacology
Hydrogen-Ion Concentration
Indomethacin - pharmacology
Male
Muscles - metabolism
Oxygen - blood
Perfusion
Physical Exertion
Prostaglandins - metabolism
Prostaglandins E - blood
Prostaglandins F - blood
Rectum - blood supply
Space life sciences
Stomach - blood supply
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Summary:Experimental evidence for the release of prostaglandin-like substances, mainly of the E type, into the venous outflow from working skeletal muscles in the dog is described. Muscular exercise of the hind-leg produced by sciatic nerve stimulation evoked the release of prostaglandin-like substances detected in femoral venous blood by the bioassay method. This release occurred during and after muscular work, was abolished by indomethacin, and was not present in gallamine-treated dogs. The results suggest that endogenous vasodilator prostaglandins released during and after muscular work may contribute to local hyperaemic response during and, mainly, after muscular activity.
Bibliography:ark:/67375/HXZ-72G8SVNN-9
istex:7847D8A74C59EEBBABCBA4E237CDA2097472F32C
ArticleID:10-4-413
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0008-6363
1755-3245
DOI:10.1093/cvr/10.4.413